WP 6 - Acute toxicological studies

Aim of the WP

Characterization of nanoparticles in the paint matrix and in the aerosol spray: the particle size distribution, the bulk and surface composition of the nanoparticles before and after mixing with the paint formulation will be determined. Nanoparticles can possibly modify their size and composition as in contact with a complex matrix, such as paint formulations. The evolution of the physicochemical parameters of the nanoparticles needs to be traced to determine differences with respect to the pristine values. To this date, there is no evidence that these properties remain unchanged in the droplets as for the generation of an aerosol. This study will serve to provide some answers and state if nanoparticles are affected by the aerosol paint application in a worker exposure condition.

Two of the well characterized paints should be selected by the WP1 to study their acute toxicity in a whole-body exposure model. The spray guns and measuring chamber for the generation of the non-volatile fraction of paints should be provided by the WP3. Information of practical paint aerosol exposure in workplaces will be delivered from WP5. The toxicological study will focused on the respiratory tract. Rodents' lungs will be collected from the whole body experiments and will be analyzed with the PIXE technique to determine the aerosol trace concentration in this organ.

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